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Ausgewählte Publikationen mit und von der BMB Nord

2025

  • Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases. Belheouane M, Kalsdorf B, Niemann S, Gaede KI, Lange C, Heyckendorf J, Merker M. Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases. PLoS One. 2025 Jun 26;20(6). doi: 10.1371/journal.pone.0325362.
  • Skevaki C, Tafo P, Bahmer T, Abdo M, Watz H, Pedersen F, Herzmann C, Rabe KF, Renz H, Nockher WA; ALLIANCE Study Group as part of the German Center for Lung Research (DZL). Differential expression of eicosanoid pathways after whole blood stimulation in asthma patients. World Allergy Organ J. 2025 Apr 2;18(4):101047. doi: 10.1016/j.waojou.2025.101047. PMID: 40235674; PMCID: PMC11999605.

 

2024

  • Lieb W, Strathmann EA, Röder C, Jacobs G, Gaede KI, Richter G, Illig T, Krawczak M. Population-Based Biobanking. Genes (Basel). 2024 Jan 3;15(1):66. doi: 10.3390/genes15010066. PMID: 38254956; PMCID: PMC10815030.
  • Carow B, Muliadi V, Skålén K, Yokota C, Kathamuthu GR, Setiabudiawan TP, Lange C, Scheu K, Gaede KI, Goldmann T, Pandita A, Masood KI, Pervez S, Grunewald J, Hasan Z, Levin M, Rottenberg ME. Immune mapping of human tuberculosis and sarcoidosis lung granulomas. Front Immunol. 2024 Feb 7;14:1332733. doi: 10.3389/fimmu.2023.1332733. PMID: 38385142; PMCID: PMC10879604.
  • Jakwerth CA, Weckmann M, Illi S, Charles H, Zissler UM, Oelsner M, Guerth F, Omony J, Nemani SSP, Grychtol R, Dittrich AM, Skevaki C, Foth S, Weber S, Alejandre Alcazar MA, van Koningsbruggen-Rietschel S, Brock R, Blau S, Hansen G, Bahmer T, Rabe KF, Brinkmann F, Kopp MV, Chaker AM, Schaub B, von Mutius E, Schmidt-Weber CB; ALLIANCE Study Group as part of the German Center for Lung Research. 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma. Am J Respir Crit Care Med. 2024 Apr 15;209(8):947-959. doi: 10.1164/rccm.202305-0934OC.
  • Alkhatib R, Gaede KI. Data Management in Biobanking: Strategies, Challenges, and Future Directions. BioTech (Basel). 2024 Sep 2;13(3):34. doi: 10.3390/biotech13030034. PMID: 39311336; PMCID: PMC11417763.

 

2023

  • Chen J, Wang X, Schmalen A, Haines S, Wolff M, Ma H, Zhang H, Stoleriu MG, Nowak J, Nakayama M, Bueno M, Brands J, Mora AL, Lee JS, Krauss-Etschmann S, Dmitrieva A, Frankenberger M, Hofer TP, Noessner E, Moosmann A, Behr J, Milger K, Deeg CA, Staab-Weijnitz CA, Hauck SM, Adler H, Goldmann T, Gaede KI, Behrends J, Kammerl IE, Meiners S. Antiviral CD8<sup>+</sup> T-cell immune responses are impaired by cigarette smoke and in COPD. Eur Respir J. 2023 Aug 3;62(2):2201374. doi: 10.1183/13993003.01374-2022. PMID: 37385655; PMCID: PMC10397470.
  • COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19. Nature. 2023 Sep;621(7977):E7-E26. doi: 10.1038/s41586-023-06355-3. Epub 2023 Sep 6. PMID: 37674002; PMCID: PMC10482689.
  • Grychtol R, Riemann L, Gaedcke S, Liu B, DeLuca D, Förster R, Maison N, Thiele D, Jakobs N, Bahmer T, Meyer M, Foth S, Weber S, Rietschel E, Rabe KF, Kopp MV, von Mutius E, Dittrich AM, Hansen G; ALLIANCE Study Group as part of the German Center for Lung Research (DZL). Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort. J Allergy Clin Immunol. 2023 Jun;151(6):1525-1535.e4. doi: 10.1016/j.jaci.2023.01.027. Epub 2023 Feb 15. PMID: 36804993.

 

2022

  • Maison N, Omony J, Illi S, Thiele D, Skevaki C, Dittrich AM, Bahmer T, Rabe KF, Weckmann M, Happle C, Schaub B, Meyer M, Foth S, Rietschel E, Renz H, Hansen G, Kopp MV, von Mutius E, Grychtol R; ALLIANCE Study Group; ALLIANCE Study Group; Fuchs O, Roesler B, Welchering N, Kohistani-Greif N, Kurz J, Landgraf-Rauf K, Laubhahn K, Liebl C, Ege M, Hose A, Zeitlmann E, Berbig M, Marzi C, Schauberger C, Zissler U, Schmidt-Weber C, Ricklefs I, Diekmann G, Liboschik L, Voigt G, Sultansei L, Nissen G, König IR, Kirsten AM, Pedersen F, Watz H, Waschki B, Herzmann C, Abdo M, Biller H, Gaede KI, Bovermann X, Steinmetz A, Husstedt BL, Nitsche C, Veith V, Szewczyk M, Brinkmann F, Malik A, Schwerk N, Dopfer C, Price M, Jirmo AC, Habener A, DeLuca DS, Gaedcke S, Liu B, Calveron MR, Weber S, Schildberg T, van Koningsbruggen-Rietschel S, Alcazar M. T2-high asthma phenotypes across lifespan. Eur Respir J. 2022 Sep 29;60(3):2102288. doi: 10.1183/13993003.02288-2021. PMID: 35210326; PMCID: PMC9520028.
  • Degenhardt F, . . . Franke A. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Hum Mol Genet. 2022 Nov 28;31(23):3945-3966. doi: 10.1093/hmg/ddac158. PMID: 35848942; PMCID: PMC9703941.
  • Tran F, Harris DMM, Scharmacher A, Graßhoff H, Sterner K, Schinke S, Käding N, Humrich JY, Cabral-Marques O, Bernardes JP, Mishra N, Bahmer T, Franzenburg J, Hoyer BF, Glück A, Guggeis M, Ossysek A, Küller A, Frank D, Lange C, Rupp J, Heyckendorf J, Gaede KI, Amital H, Rosenstiel P, Shoenfeld Y, Halpert G, Rosenberg AZ, Schulze-Forster K, Heidecke H, Riemekasten G, Schreiber S. Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19. ERJ Open Res. 2022 Dec 27;8(4):00379-2022. doi: 10.1183/23120541.00379-2022. PMID: 36575710; PMCID: PMC9571165.
  • Brandenburg J, Heyckendorf J, Marwitz F, Zehethofer N, Linnemann L, Gisch N, Karaköse H, Reimann M, Kranzer K, Kalsdorf B, Sanchez-Carballo P, Weinkauf M, Scholz V, Malm S, Homolka S, Gaede KI, Herzmann C, Schaible UE, Hölscher C, Reiling N, Schwudke D. Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis. ACS Infect Dis. 2022 Jul 8;8(7):1303-1315. doi: 10.1021/acsinfecdis.2c00075. Epub 2022 Jun 28. PMID: 35763439; PMCID: PMC9274766.
  • Pfeiffer S, Herzmann C, Gaede KI, Kovacevic D, Krauss-Etschmann S, Schloter M. Different responses of the oral, nasal and lung microbiomes to cigarette smoke. Thorax. 2022 Feb;77(2):191-195. doi: 10.1136/thoraxjnl-2020-216153. Epub 2021 Aug 13. PMID: 34389656; PMCID: PMC8762037.
  • Habener A, Grychtol R, Gaedcke S, DeLuca D, Dittrich AM, Happle C, Abdo M, Watz H, Pedersen F, König IR, Thiele D, Kopp MV, von Mutius E, Bahmer T, Rabe KF, Meyer-Bahlburg A, Hansen G; ALLIANCE Study Group as part of the German Center for Lung Research (DZL); Fuchs O, Roesler B, Welchering N, Kohistani-Greif N, Kurz J, Landgraf-Rauf K, Laubhahn K, Maison N, Liebl C, Schaub B, Ege M, Illi S, Hose A, Zeitlmann E, Berbig M, Marzi C, Schauberger C, Zissler U, Schmidt-Weber C, Ricklefs I, Diekmann G, Liboschik L, Voigt G, Sultansei L, Weckmann M, Nissen G, Kirsten AM, Waschki B, Herzmann C, Biller H, Gaede KI, Bovermann X, Steinmetz A, Husstedt BL, Nitsche C, Veith V, Szewczyk M, Brinkmann F, Malik A, Schwerk N, Dopfer C, Price M, Jirmo AC, Liu B, Calveron MR, Weber S, Foth S, Skevaki C, Renz H, Meyer M, Schildberg T, Rietschel E, van Koningsbruggen-Rietschel S, Alcazar M. IgA<sup>+</sup> memory B-cells are significantly increased in patients with asthma and small airway dysfunction. Eur Respir J. 2022 Nov 3;60(5):2102130. doi: 10.1183/13993003.02130-2021. PMID: 35595320; PMCID: PMC9630610.
  • Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28. PMID: 36577072; PMCID: PMC9910463.
  • Freundt K, Herzmann C, Biedziak D, Scheffzük C, Gaede KI, Stamme C. Surfactant Protein A Enhances the Degradation of LPS-Induced TLR4 in Primary Alveolar Macrophages Involving Rab7, β-arrestin2, and mTORC1. Infect Immun. 2022 Feb 17;90(2):e0025021. doi: 10.1128/IAI.00250-21. Epub 2021 Nov 15. PMID: 34780278; PMCID: PMC8853680.
  • Weckmann M, Thiele D, Liboschik L, Bahmer T, Pech M, Dittrich AM, Fuchs O, Happle C, Schaub B, Ricklefs I, Rabe KF, von Mutius E, Hansen G, König IR, Kopp MV; ALLIANCE Study Group. Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time. Clin Exp Immunol. 2021 Apr;204(1):152-164. doi: 10.1111/cei.13550. Epub 2020 Dec 15. PMID: 33202033; PMCID: PMC7944353.

 

2021

  • COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021 Dec;600(7889):472-477. doi: 10.1038/s41586-021-03767-x. Epub 2021 Jul 8. PMID: 34237774; PMCID: PMC8674144.
  • Frye BC, Gaede KI, Saltini C, Rossman MD, Monos DS, Rosenman KD, Schuler CR, Weston A, Wegner R, Noth R, Zissel G, Schreiber S, Nothnagel M, Müller-Quernheim J. Analysis of single nucleotide polymorphisms in chronic beryllium disease. Respir Res. 2021 Apr 16;22(1):107. doi: 10.1186/s12931-021-01691-2. PMID: 33863318; PMCID: PMC8051053.
  • Maison N, Herbrüggen H, Schaub B, Schauberger C, Foth S, Grychtol R, Abdo M, Watz H, Nikolaizik W, Rabe KF, Kopp MV, Hansen G, von Mutius E, Bahmer T, Omony J; ALLIANCE study group. Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma. Allergy Asthma Clin Immunol. 2021 Sep 16;17(1):93. doi: 10.1186/s13223-021-00592-9. PMID: 34530911; PMCID: PMC8444172.

 

2020

  • Jünger C, Reimann M, Krabbe L, Gaede KI, Lange C, Herzmann C, Rüller S. Correction: Non-invasive ventilation with pursed lips breathing mode for patients with COPD and hypercapnic respiratory failure: A retrospective analysis. PLoS One. 2021 Feb 19;16(2):e0247693. doi: 10.1371/journal.pone.0247693. Erratum for: PLoS One. 2020 Sep 21;15(9):e0238619. doi: 10.1371/journal.pone.0238619. PMID: 33606851; PMCID: PMC7894957.

 

2019

  • Lieb W, Jacobs G, Wolf A, Richter G, Gaede KI, Schwarz J, Arnold N, Böhm R, Buyx A, Cascorbi I, Franke A, Glinicke C, Held-Feindt J, Junker R, Kalthoff H, Kramer HH, Leypoldt F, Maass N, Maetzler W, May S, Mehdorn HM, Röcken C, Schafmayer C, Schrappe M, Schreiber S, Sebens S, Stephani U, Synowitz M, Weimer J, Zabel P, Nöthlings U, Röder C, Krawczak M. Linking pre-existing biorepositories for medical research: the PopGen 2.0 Network. J Community Genet. 2019 Oct;10(4):523-530. doi: 10.1007/s12687-019-00417-8. Epub 2019 Mar 29. PMID: 30927239; PMCID: PMC6754520.
  • Webering S, Lunding LP, Vock C, Schröder A, Gaede KI, Herzmann C, Fehrenbach H, Wegmann M. The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clin Exp Allergy. 2019 Jul;49(7):1026-1039. doi: 10.1111/cea.13400. Epub 2019 May 6. PMID: 30980429.

 

2018

  • Schupp JC, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho LP, Gaede KI, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane MP, O'Beirne S, Donnelly S, Haraldsdottir SO, Jorundsdottir KB, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. Eur Respir J. 2018 Jan 25;51(1):1700991. doi: 10.1183/13993003.00991-2017. PMID: 29371378.
  • Salzer HJF, Prattes J, Flick H, Reimann M, Heyckendorf J, Kalsdorf B, Obersteiner S, Gaede KI, Herzmann C, Johnson GL, Lange C, Hoenigl M. Evaluation of Galactomannan Testing, the Aspergillus-Specific Lateral-Flow Device Test and Levels of Cytokines in Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis. Front Microbiol. 2018 Oct 2;9:2223. doi: 10.3389/fmicb.2018.02223. PMID: 30333797; PMCID: PMC6176022.

 

2017

  • Zimmermann A, Knecht H, Häsler R, Zissel G, Gaede KI, Hofmann S, Nebel A, Müller-Quernheim J, Schreiber S, Fischer A. Atopobium and Fusobacterium as novel candidates for sarcoidosis-associated microbiota. Eur Respir J. 2017 Dec 14;50(6):1600746. doi: 10.1183/13993003.00746-2016. PMID: 29242257.

 

2016

  • Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Müller-Quernheim J, Zissel G. Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. Am J Respir Cell Mol Biol. 2016 Nov;55(5):749-757. doi: 10.1165/rcmb.2015-0278OC. PMID: 27390897.
  • Krause T, Röckendorf N, Gaede KI, Ramaker K, Sinnecker H, Frey A. Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases. MAbs. 2017 Feb/Mar;9(2):333-341. doi: 10.1080/19420862.2016.1264551. Epub 2016 Dec 2. PMID: 27911216; PMCID: PMC5297535.
  • Ganbat D, Seehase S, Richter E, Vollmer E, Reiling N, Fellenberg K, Gaede KI, Kugler C, Goldmann T. Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells. BMC Pulm Med. 2016 Jan 23;16:19. doi: 10.1186/s12890-016-0185-5. PMID: 26803467; PMCID: PMC4724406.